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Pharmacogenetics and statins: Genotyping might cut muscle-pain risk

20.08.20131920
Strikingly wide variation among patients in plasma levels of atorvastatin and rosuvastatin (Crestor, AstraZeneca), even with consistent dosing, is likely related to gene variants that affect the drugs' uptake by the liver in some patients, suggests a prospective study.

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease

19.08.20132141
The first aim was to critically evaluate the extent to which familial hypercholesterolaemia (FH) is underdiagnosed and undertreated. The second aim was to provide guidance for screening and treatment of FH, in order to prevent coronary heart disease (CHD).

Rheumatoid arthritis may double VTE risk

16.08.20132031
Rheumatoid arthritis (RA) was associated with a significantly increased risk for potentially fatal blood clots in the legs and lung in a nationwide prospective cohort study from Taiwan published online August 7, 2013 in the Annals of the Rheumatic Diseases.

Alternative models of cardiac rehabilitation: a systematic review

15.08.20132155
The traditional hospital-based model of cardiac rehabilitation faces substantial challenges, such as cost and accessibility.

Hypertensive Retinopathy and Risk of Stroke

14.08.20132141
Although assessment of hypertensive retinopathy signs has been recommended for determining end-organ damage and stratifying vascular risk in persons with hypertension, its value remains unclear.

Sugar Activates Oncogenes in Tumors

13.08.20131954
Sugar consumption fueled tumor growth in fruit flies, possibly explaining why people with metabolic syndrome have an increased risk for certain cancers, according to a new study.

The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension

12.08.20131849
Oxidative stress is implicated in the pathology of pulmonary arterial hypertension (PAH).
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